Research in Pancreatic diseases
Acute and chronic pancreatitis
- MCP-1 regulation in pancreatic acinar cells
- Pancreatitis-associated protein does not protect the pancreas in CF-mice
- We demonstrated the presence of PGE2 receptors in chronic pancreatic inflammation.
- We were able to demonstrate a synergistic effect of TNF and PGE2 in primary pancreatic lobuli.
- Apoptosis is inhibited by alcohol and tissue injury is switched to a necrotic type of cell death. Publication in Am. J. Physiology.
- Grants awarded from the Swiss National Science Foundation and the Velux Foundation
- Dr. Aurel Perren, Institut für klinische Pathologie, Universitätsspital Zürich
- Dr. Pia März & Prof. U. Otten, Physiologisches Institut, Universität Basel
- PD Dr. Marius Keel & Dr. Luc Härter, Klinik für Unfallchirurgie, Universitätsspital Zürich
- Dr. Martin Hersberger, Institut für Klinische Chemie, Universitätsspital Zürich
- Dr. Robert DeLisle, Anatomy and Cell Biology, University of Kansas School of Medicine, Kansas City, KS
- Prof. M. Bachem, Klinische Chemie, Universitätsklinikum, Ulm
- Selected References
- Graf R, Schiesser M, Reding T, Appenzeller P, Sun LK, Fortunato F, Perren A, Bimmler D. Exocrine Meets Endocrine: Pancreatic Stone Protein and Regenerating Protein-Two Sides of the Same Coin. J Surg Res 2006, 133: 113-120
- Reding TV, Bimmler DR, Perren A, Sun LK, Fortunato F, Storni F, Graf R. A selective COX-2 inhibitor suppresses chronic pancreatitis in an animal model (WBN/Kob rats): significant reduction of macrophage infiltration and fibrosis. Gut 2006, 55: 1165-73
- Fortunato F, Deng X, Gates LK, McClain CJ, Bimmler D, Graf R, et al. Pancreatic Response to Endotoxin after Chronic Alcohol Exposure: Switch from Apoptosis to Necrosis? Am J Physiol Gastrointest Liver Physiol 2006, 90: G232-41.
Islet Cell Transplantation
- Tissue engineering in therapeutic islets transplantation
- We were able to demonstrate the feasibility of generating islets of defined dimensions with decreased susceptibility to ischemic injury.
- In vitro generated pseudoislets show an increased glucose stimulated insulin secretion.
- Financial support was obtained from the Olga-Mayenfisch Stiftung.
- The research project is also part of a close collaboration with PD Dr. Lehmann and Dr. Züllig of the Unit of Endocrinology and Diabetology in Internal Medicine of the University Hospital Zürich and Dr. Kelm from the Tissue Engineering Group of Cardiovascular Research by Prof. Hoerstrup.
- Selected References
- Moritz W., Meier F., Stroka D. M., Giuliani M., Kugelmeier P., Nett P.C., Lehmann R., Candinas D., Gassmann M., Weber M. (2002)
- Apoptosis in hypoxic human islets correlates with HIF-1 alpha expression. FASEB J. 2002 May; 16:745- 7
- Giuliani M, Moritz W, Bodmer E, Dindo D, Kugelmeier P, Lehmann R, Gassmann M, Groscurth P, Weber M. Central necrosis in isolated hypoxic human pancreatic islets: Evidence for post-isolation ischemia. Cell Transplant: 14: 67-76, 2005